DJETEPAR inyeksiya uchun eritma 10ml N5
DJETEPAR inyeksiya uchun eritma 10ml N5 qo'llanmasi
Farmakokinetikasi
Betain glyukuronati (glyukometamin) organizmga tushganda ingichka ichak shilliq qavati enterotsitlari tomonidan oson so'riladi va qonga tushadi. Qon oqimi bilan jigarga o'tadi, u yerda betain va glyukuron kislotasigacha parchalanadi. Molekula metil guruhini betain gomosisteinga beradi, shu tariqa jigarga toksik ta'sirni kamaytiradi. Betain glyukuronati (Glyukometamin) metabolizmi mahsulotlari L-metionin va dimetilglitsin bo'lib, ular safro bilan chiqariladi. Nikotinamid struktur jihatdan nikotin kislotasiga yaqin. Ichak shilliq qavati orqali yaxshi so'riladi. U barcha to'qimalarga tez taqsimlanadi, platsenta to'sig'i orqali va ko'krak sutiga o'tadi. Jigarda nikotinamid -N-metilnikotinamid hosil bo'lishi bilan metabollanadi. Buyraklar orqali ekskretsiya qilinadi.
Farmakologik ta'siri
Jetepar® o‘ziga xos antitoksik ta’sir ko‘rsatadi. Glyukometamin (betain glyukuronati) jigarga tushgach, betain va glyukuron kislotasiga parchalanadi. Betain samarali lipotrop va detoksikatsion ta’sirga ega, shuningdek metil guruhlari donori hisoblanadi. Glyukometamin jigarda sodir bo‘ladigan dezintoksikatsion reaksiyalarda ishtirok etuvchi asosiy modda bo‘lgan glyukuron kislotasi tufayli kuchli detoksikatsion va glikogen ta’sirga ega. Glyukodiamin (dietanolamin glyukuronati) glyukuron kislotasining dezintoksikatsion va gepatoprotektor ta’sirini to‘ldiradi. Dietanolamin jigar lipidlari darajasining (ham aortal xolesterin, ham qon zardobidagi xolesterin) sezilarli pasayishiga olib keladi. Nikotinamid askorbat shaklida antitoksik, entrofik va asteniyaga qarshi ta’sirga ega. I (NAD) va II (NADP) nikotinamid hujayralardagi oksidlanish-qaytarilish jarayonlarida va yog‘lar, proteinlar, aminokislotalar, purinlar metabolizmida, to‘qima nafasida va glikogenezda ishtirok etadi. Jetepar® bir necha kun qo‘llanilgandan so‘ng endogen toksinlarning organizmdan tez chiqarilishiga yordam beradi, jigar funksiyasining tez yaxshilanishiga erishiladi.
Nojo'ya samaralari
Jetepar odatda yaxshi o'zlashtiriladi. Kamdan-kam hollarda quyidagi noxush reaksiyalar qayd etilgan: oshqozonda noqulaylik hissi, axlat yumshashi yoki diareya. Parenteral yuborilgandan keyin allergik teri reaksiyalari bo'lishi mumkin. Bunday hollarda preparatning oral shakllarini buyurish kerak.
Maxsus saqlash sharoitlari
Shifokor ko'rsatmasi bo'yicha qo'llash kerak. Keksa yoshdagi bemorlar, buyrak yetishmovchiligi va boshqa og'ir yo'ldosh patologiyalardan aziyat chekuvchi bemorlar uchun eng kichik samarali dozalarni qo'llash zarurati bo'lishi mumkin.
Qo'llanilishi mumkin bo'lmagan holatlar
Suvsiz betainga yoki betainning boshqa shakllariga allergiyasi yoki yuqori sezuvchanligi bo'lgan odamlarga qo'llashdan saqlanish kerak.
Dori vositalarining o'zaro ta'siri
Klinik ahamiyatli dori vositalari bilan o‘zaro ta’sir turlari qayd etilmagan. Shunga qaramay, jigar faoliyatiga ta’sir ko‘rsatgan holda, Jetepar® turli xil dori vositalari, shu jumladan antatsid vositalar, H2-retseptorlar antagonistlari, yurak-qon tomir kasalliklarini davolash uchun preparatlarning metabolizmiga ta’sir qilishi mumkin. Serotoninni qayta qamrab oluvchi selektiv ingibitorlar va tritsiklik antidepressantlar bilan bir vaqtda qo‘llanilganda ehtiyotkorlik bilan buyurish tavsiya etiladi. Vena ichiga yuborish uchun eritma shaklidagi preparat ko‘pchilik infuzion eritmalar (Ringer eritmasi, Xartman eritmasi, 0,9% li natriy xlorid eritmasi, turli konsentratsiyadagi glyukoza eritmalari) bilan mos keladi.
Dozirovkasi
O'tkir zaharlanishlar va jigar funksiyasi turli buzilishlarining og'ir holatlari:
V/i in'ektsiya uchun eritma (10 ml li ampulalar): har kuni sutkasiga 1 – 5 ampuladan tomir ichiga (oqim bilan yoki infuzion).
Yengilroq buzilishlar va tutib turuvchi terapiya uchun:
M/o in'ektsiya uchun eritma (2 ml li ampulalar) sutkasiga 1 – 2 ampuladan mushak orasiga.
Hajm/og'irlik
DJETEPAR inyeksiya uchun eritma 10ml N5 o'xshash dorilari
DJETEPAR inyeksiya uchun eritma 10ml N5 xususiyatlari
Jetepar boshqa chiqarish shakllari
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]DJETEPAR inyeksiya uchun eritma 10ml N5 narxlari va Toshkentdagi dorixonalardagi mavjudligi
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