Seftriakson-Novo

Tseftriakson - beta – laktamlar guruhiga mansub yarimsintetik antibiotik, III avlod sefalosporini, bakteritsid samaraga ega. Ta'sir mexanizmi transpeptidaza fermenti faolligini susaytirish, mikroorganizmlar hujayra devori peptidoglikani biosintezini buzish bilan bog'liq. Preparat keng ta'sir doirasiga ega: aerob grammusbat mikroorganizmlarga nisbatan faol: fakultativ anaeroblar - Straphylococcus aureus (shu jumladan penitsillinaza hosil qiluvchi shtammlar), Staphylococcus epidermidis, Streptococcus pneumoniaе, b-gemolitik A guruh streptokokklar (S. pyogenes), B guruh streptokokklar (S. agalactiae), Streptococcus viridans, Streptococcus bovis, D guruh noenterokokk streptokokklar; grammanfiy mikroorganizmlar: Escherichia coli, Haemophilus influenzae, H. рarainfluenzae, Klebsiella turlari (shu jumladan Kb. pneumoniae), Morganella morganii, Proteus mirabilis, Proteus vulgaris, Providencia, Salmonella (shu jumladan S.typhy), Serratia (shu jumladan S.marcesceos), Shigella, Versinia (shu jumladan Y. enterocolitica); mikroaerofillar – Treponema pallidum; aeroblar - Neisseria gonorrheae (shu jumladan penitsillin hosil qiluvchi shtamm), Neisseria meningitides, Pseudomonas aeruginosa; obligat anaeroblar-bakteroidlar turlari (shu jumladan B. Fragilis ning ba'zi shtammlari), Clostridium, lekin С difficile ning ko'pchilik shtammlari rezistentlikka ega), Peptococcus, Peptostreptococcus, Fusobacterium (shu jumladan F. mortiferum va F. varium). Preparat mikroorganizmlar sefalosporin qatorining boshqa preparatlariga, aminoglikozidlar, penitsillinlarga va b. rezistent bo'lganda tayinlanadi.