ASPIRIN S tabletkalari N10
ASPIRIN S tabletkalari N10 qo'llanmasi
Farmakokinetikasi
Farmakokinetika to'g'risidagi ma'lumotlar taqdim etilmagan.
Nojo'ya samaralari
Oshqozon-ichak trakti tomonidan: qorinda og'riqlar, ko'ngil aynishi, qusish, oshqozon-ichakdan qon ketishning yaqqol (qora axlat, qon qusish) yoki yashirin belgilari, bu temir tanqisligi anemiyasiga olib kelishi mumkin, oshqozon-ichak traktining eroziv-yarali shikastlanishlari (shu jumladan perforatsiya bilan), kam hollarda – jigar funktsiyasining buzilishi (jigar transaminazalarining oshishi).
Markaziy asab tizimi tomonidan: bosh aylanishi, quloqlarda shovqin (odatda doza oshirib yuborilganining belgilaridir).
Qon yaratish tizimi tomonidan: gemorragik sindrom, trombotsitopeniya.
Siydik chiqarish tizimi tomonidan: yuqori dozalarda qo'llanilganda – giperoksaluriya va kaltsiy oksalatdan siydik toshlari hosil bo'lishi, buyrak glomerulyar apparatining shikastlanishi.
Allergik reaksiyalar: teri toshmasi, anafilaktik reaksiyalar, bronxospazm, Kvinke shishi.
Shunday belgilar paydo bo'lganda preparatni qabul qilishni to'xtatish va darhol davolovchi shifokorga murojaat qilish tavsiya etiladi.
Maxsus saqlash sharoitlari
Preparat virusli infektsiyalar chaqirgan o'tkir respirator kasalliklari bo'lgan 15 yoshgacha bo'lgan bolalarga istima tushiruvchi vosita sifatida tayinlanmaydi, bu Reye sindromi (jigar yetishmovchiligining o'tkir rivojlanishi bilan ensefalopatiya va jigarning o'tkir yog'li distrofiyasi) rivojlanish xavfi tufaylidir.
Asetilsalitsil kislotasi organizmdan siydik kislotasi chiqarilishini kamaytiradi, bu moyilligi bo'lgan bemorlarda podagra o'tkir xurujining sababi bo'lishi mumkin.
Preparat uzoq muddat qo'llanilganda vaqti-vaqti bilan umumiy qon tahlili va yashirin qonga axlat tahlilini qilish, jigar funksional holatini nazorat qilish kerak.
Asetilsalitsil kislotasi qon ivishini sekinlashtirishi sababli, agar bemorni jarrohlik aralashuvi kutayotgan bo'lsa, u oldindan shifokorni preparat qabul qilayotgani haqida ogohlantirishi kerak.
Davolash vaqtida etanoldan voz kechish kerak (me'da-ichakdan qon ketish xavfining oshishi).
Homiladorlikning ikkinchi trimestrida preparatni tavsiya etilgan dozalarda bir marta qabul qilish faqat ona uchun kutilayotgan foyda homila uchun potentsial xavfdan ustun bo'lgan holdagina mumkin.
Preparatning bir dozasi 933 mg natriy saqlaydi, buni tuzsiz parhez olayotgan bemorlar hisobga olishlari kerak.
Preparatni laktatsiya davrida qo'llash zarurati bo'lganda emizishni to'xtatish kerak.
Qo'llanilishi mumkin bo'lmagan holatlar
atsetilsalitsil kislotasi va boshqa NYQP larga yuqori sezuvchanlik;
-me'da-ichak traktining eroziv-yarali shikastlanishlari (zo'rayish bosqichida), me'da-ichakdan qon ketishlar;
-burun poliplari bilan birga salitsilatlar yoki boshqa NYQP qabul qilish chaqirgan astma;
-metotreksatni haftasiga 15 mg va undan ortiq dozada birgalikda qo'llash;
-jigar yoki buyrak faoliyatining yaqqol buzilishlari;
-gemorragik diatezlar;
-gemofiliya, trombotsitopeniya;
-glyukoza-6-fosfatdegidrogenaza tanqisligi;
-homiladorlik (I va III trimestr), emizish davri,
-bolalar yoshi (15 yoshgacha).
Ehtiyotkorlik bilan
Antikoagulyantlar bilan yo'ldosh terapiyada, podagrada, me'da va/yoki o'n ikki barmoqli ichak yara kasalligi (anamnezda), eroziv gastritda va me'da-ichakdan qon ketishga moyillikda, gipoprotrombinemiyada, K gipovitaminozida, anemiyada, organizmda suyuqlik tutilishiga moyillik yaratuvchi holatlarda (shu jumladan yurak faoliyatining buzilishi, arterial gipertenziyada), tireotoksikozda.
Dori vositalarining o'zaro ta'siri
Metotreksat toksikligini, narkotik analgetiklar, boshqa NYAQV, peroral gipoglikemik preparatlar, geparin, bilvosita antikoagulyantlar, trombolitiklar va trombotsitlar agregatsiyasi ingibitorlari, sulfanilamidlar (shu jumladan ko-trimoksazol), triyodtironin, rezerpin samaralarini kuchaytiradi; urikozurik preparatlar (benzbromaron, sulfinpirazon), gipotenziv vositalar va diuretiklar (spironolakton, furosemid) samaralarini kamaytiradi.
Glukokortikosteroidlar, alkogol va alkogol saqlovchi preparatlar MTY shilliq qavatiga shikastlovchi ta'sirni oshiradi, me'da-ichakdan qon ketishlar rivojlanish xavfini oshiradi.
Qon plazmasida digoksin, barbituratlar va litiy preparatlari konsentratsiyasini oshiradi. Magniy va/yoki alyuminiy gidroksidi saqlovchi antatsidlar asetilsalitsil kislotasi so'rilishini sekinlashtiradi va yomonlashtiradi.
Askorbin kislotasi ichakda temir preparatlari so'rilishini yaxshilaydi.
Dozirovkasi
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]ASPIRIN S tabletkalari N10 narxlari va Toshkentdagi dorixonalardagi mavjudligi
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